Cell immunity of laboratory animals under the influence of 5-indolylmethylene rhodanine-3-carboxylic/sulphonic acid derivative

The aim. To study the cell immunity status under influence of 3-[5-(1H-indol-3-ylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]-propionic acid, as a prominent 4-thiazolidinone derivative and class biologically active compounds with polypharmacological properties. Materials methods. Experimental method on model laboratory animals (guinea pigs); intradermal allergy tests; relative absolute content in peripheral blood T- B-lymphocytes subpopulations; hematological indexies: index ratio lymphocytes monocytes, neutrophils eosinophils, phagocytic index, number; ELISA; organic synthesis; pharmacological screening. Results. effect acid has antifungal properties affect cellular component vivo guinea pigs model. There are no changes skin during after chemical applications tests. compound stimulate immune cells, particular lymphocyte (increase number CD3 T-lymphocytes by 21.46 % CD8 T-suppressors 27.15 %), but selective inhibitory certain units (decrease NK cells CD16 11.57 CD22 23.08 %). was an increase activity macrophage system PN 439.87 PI 62.73 at 120 minutes), which indicates reliability absorbing function phagocytes, decrease their ability to endocytosis (PCI decreased significantly 78,72 Conclusions. Synthesized activating parts activity. Derivate is ambiguous, directed part does not cause immunodeficiency. studied promising for further drug-like molecule antitumor effects